msilynchsyndrome

由 JM Carethers 著作 · 2019 · 被引用 7 次 — Lynch syndrome is one of five human conditions in which tumors manifest a defect in MMR function that can be detected by microsatellite instability (MSI) ...

Cancers associated with Lynch syndrome frequently have a specific pattern of mutations known as microsatellite instability (MSI), also known as mismatch repair ...

由 V Roudko 著作 · 2021 · 被引用 42 次 — Lynch syndrome or hereditary non-polyposis colorectal cancer (HNPCC) is characterized by germline inactivation of one allele of genes involved ...

MSI screening is used to see if the Lynch syndrome genes are working properly. Microsatellites are regions of repeated DNA that change in length (show ...

由 CR Boland 著作 · 2010 · 被引用 2396 次 — MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome and the other 12% are caused by sporadic, acquired ...

由 A Latham 著作 · 2019 · 被引用 446 次 — ... Lynch syndrome (LS)-associated cancer predisposition. The recent success of immunotherapy in high-frequency MSI (MSI-H) and/or MMR-D tumors ...

由 K Li 著作 · 2020 · 被引用 321 次 — Lynch syndrome is an autosomal dominant tumor syndrome caused by mutations in MMR strains, and it can also cause tumors in other parts of the ...

Immunohistochemistry is a screening test for Lynch syndrome tumors that looks for the proteins expressed by the major mismatch repair (MMR) genes. If the genes ...

All involve the testing of tumor tissue. MSI: Approximately 90% of colon tumors from individuals with Lynch Syndrome demonstrate microsatellite instability (MSI) ...